Eastern Equatoria health partners intensified efforts to combat the cholera outbreak that killed at least 13 people in the state.
State Health Minister Margaret Itto said it is a big challenge requiring increased community sensitization, enough human resources and medical supplies to address the situation.
She said the disease was spreading faster in the state because of poor hygiene, including open defecation, drinking unsafe water and community mismanagement of dead bodies.
Dr Itto appealed to community members to wash hands at all times using soap or ash with clean water, eat hot food, listening to home health promoters and immediately report suspected cases.
All schools and some restaurants were closed to avoid more spread of the disease.
The National Health Ministry confirmed the outbreak in Juba, Central Equatoria in May which spread quickly to Jonglei, Upper Nile and now Eastern Equatoria.
At least over 50 people from the four affected states died of confirmed and suspected cholera and over 2,000 cases recorded.
South Sudan Health Link in partnership with UNICEF set up six Oral Rehydration Points and Cholera Treatment Centres in Iligum, Lobolua, Inyif, Hai Lotuko, Hai Mission and Ibalach.