Medicines Sans Frontiers or MSF head of mission in South Sudan said highly vulnerable people became more vulnerable.
Raphael Gorge said continued fighting caused serious consequences and resources become scarce following departure of many organizations.
In a statement on Tuesday, he said there was high risk of diseases and conditions would deteriorate if the fighting continues to prevent them from accessing people in need.
Mr Gorge said MSF teams delivered more than 40 tons of medical and logistical supplies.
He said MSF remained committed to continue providing assistance, calling on all parties to respect its medical facilities.
MSF’s emergency teams are currently working in Juba, Awerial and Malakal to provide medical care to more than 110 thousand displaced people.